venofer dosing calculator

For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Use Caution/Monitor. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Slowing the infusion rate may alleviate symptoms. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Minor/Significance Unknown. FERAHEME Dosing & Administration - Feraheme in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . The recipient will receive more details and instructions to access this offer. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia Separate by 2 hr. Iron Deficiency Calculator Avoid or Use Alternate Drug. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Iron Sucrose Monograph for Professionals - Drugs.com IDA diagnosis is based on full blood examination and on the serum ferritin level. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Ferric gluconate: 12.5 mg/mL. 2.1 . STORAGE: Consult the product instructions and your pharmacist for storage details. May increase risk of hypotension. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. commonly, these are "preferred" (on formulary) brand drugs. Applies only to oral form of both agents. Accessed: 4/12/2011. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Either increases effects of the other by pharmacodynamic synergism. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Your doctor will do laboratory tests to monitor your response. 3. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Minor/Significance Unknown. Applies only to oral form of both agents. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. official version of the modified score here. Avoid or Use Alternate Drug. Written by ASHP. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Applies only to oral form of both agents. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. 1970; 100(7):301-3. Minor/Significance Unknown. Use Caution/Monitor. Anemias. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Patients measured hemoglobin can be input in g/dL or mmol/L. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Use Caution/Monitor. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Applies only to oral form of both agents. Am J Kid Dis 2001; 38 988991. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Intravenous iron sucrose for children with iron deficiency failing to Most Applies only to oral form of both agents. Modify Therapy/Monitor Closely. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Oral and parenteral products - see background option for oral products. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Do not mix iron sucrose with other medications or TPN solution. Applies only to oral form of both agents. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Either decreases levels of the other by inhibition of GI absorption. Applies only to oral form of both agents. DailyMed - VENOFER- IRON SUCROSE injection, solution Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com Minor (1)iron sucrose, captopril. Properly discard this product when it is expired or no longer needed. Modify Therapy/Monitor Closely. Iron Sucrose - SlideShare This product may contain inactive ingredients, which can cause allergic reactions or other problems. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Use Caution/Monitor. Creating an account is free and takes less than 1 minute. We comply with the HONcode standard for trustworthy health information. The elemental iron product used is Iron sucrose 20 mg/mL. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). Applies only to oral form of both agents. Administer on 5 different occasions over a 14 day period. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Monitor for signs and symptoms of hypotension following each administration of Venofer. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. ONE DOSE. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Discard unused portion. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. DailyMed - VENOFER- iron sucrose injection, solution VenAccess is a trademark of Vifor (International) Inc. Switzerland. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Fill in the calculator/tool with your values and/or your answer choices and press Calculate. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Our dosage calculator can help you with this as well. Fulminant symptoms may include general paleness, confusion or episodes of passing out. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Use Caution/Monitor. Use alternatives if available. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. FERAHEME met the predefined criteria for non-inferiority to Venofer . Administer Venofer early during the dialysis session (generally within the first hour). Slow or stop the infusion if adverse reactions occur. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Keep all medical and lab appointments. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. Applies only to oral form of both agents. 1. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Total dose iron infusion: safety and efficacy in predialysis patients. Either increases effects of the other by pharmacodynamic synergism. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Please confirm that you would like to log out of Medscape. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Avoid or Use Alternate Drug. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW prescription products. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Monitor for signs and symptoms of hypotension following each Feraheme infusion. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Modify Therapy/Monitor Closely. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Iron Product. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Many patients with kidney disease cannot get enough iron from food and require injections. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Avoid or Use Alternate Drug. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 1000 mg. 20 MINUTES. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Dosing Administration & Considerations . Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Copyright 1993-2021 A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Deferoxamine chelates iron. Nutr Clin Pract. May increase risk of hypotension. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Use Caution/Monitor. These can be input in g/dL, g/L or mmol/L. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). Avoid or Use Alternate Drug. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Intravenous iron sucrose for children with iron deficiency anemia: a Applies only to oral form of both agents. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. May increase risk of hypotension. Venofer may cause clinically significant hypotension. Ganzoni Equation for Iron Deficiency Anemia - MDCalc Iron sucrose: 20 mg/mL. Applies only to oral form of both agents. Venofer must only be administered intravenously either by slow injection or by infusion. Applies only to oral form of both agents. Crown Rump Length and Nuchal Translucency. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Applies only to oral form of both agents. Use Caution/Monitor. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Read our. Use Caution/Monitor. and formulary information changes. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. UpToDate. Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Contraindicated. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Share cases and questions with Physicians on Medscape consult. Official Journal of the International Society of Nephrology. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. David McAuley, Pharm.D. Volume of iron product required = 25 mL. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Avoid or Use Alternate Drug. Applies only to oral form of both agents. There is in depth information below the form on the method used and on the result provided. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. The dosage of iron sucrose is expressed in mg of elemental iron. No data are available regarding overdosage of Venofer in humans. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Minor/Significance Unknown. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. PDF Iron Sucrose: Guidelines for Administration Document Type: Guideline Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Applies only to oral form of both agents. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Suggested regime: Prescribing instructions Prescribing a single/first dose: 1 ,*. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. LBW = Lean body weight in kg. J Lab Clin Med. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer Dosing and Administration Applies only to oral form of both agents. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? . Clinical calculators for obstetrics and gynaecology - calculosaurus Recommended dosing and infusion rates for PI. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Venofer (iron sucrose) dose, indications, adverse effects - PDR Dosage form: injection, solution One dose IV Iron replacement | Monoferric Reactions have occurred following the first dose or subsequent doses of Venofer. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Each mL contains 20 mg of elemental iron. Consult your pharmacist or local waste disposal company. Applies only to oral form of both agents. Can't find what you need? Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Applies only to oral form of both agents. Dosage Calculator Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. By clicking send, you acknowledge that you have permission to email the recipient with this information. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Dosing: (a) Divide calculated total cumulate dose .

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